Prof. Laura Civiero, Department of Biology, laura.civiero@unipd.it (Lecture 7 CFU)
Prof. Marco Mainardi (Lecture 2 CFU + Lab 0.25 CFU), Marco Dal Maschio (Lab 0.25 CFU), Elisa Greggio (Lab 0.25 CFU)
10 CFU: 9 CFU lecture-based lessons and 1 CFU laboratory
Specific sections will be:
•Anatomical and functional organization of the human nervous system (0.5 CFU).
•Cellular organization of the nervous system – neurons and glia biology, the blood-brain barrier (1 CFU).
•The properties of nerve cells, including the generation and conduction of propagated signaling (0.5 CFU).
•Evolution of the nervous system (0.5 CFU).
•Electrophysiological and molecular mechanisms of synaptic transmission, including neuronal excitability, neurotransmitters, and transmitter release (0.5 CFU).
•Functional, structural, and molecular aspects of synaptic plasticity. Short- and long-term plasticity; structure and plasticity of dendritic spines; key molecular mediators of synaptic plasticity; experimental techniques for studying the synapse proteome.
Learning and memory. Main types of memory; behavioral methods for the study of memory; relationship between synaptic plasticity and memory.
Memory engrams: definition, experimental techniques for engram study, limitations of current approaches to the study of engrams (1.5 CFU).
•Sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system (0.5 CFU).
•Neural mechanisms of movement and basal ganglia regulation (0.5 CFU).
•Advanced approaches in neurobiology: electrophysiology techniques, optogenetic techniques, imaging techniques, quantitative neurobiology, molecular neuroscience (e.g., methods for preparing purified cell cultures of defined neuronal and glial cells; preparation and stereotaxic delivery of lentiviral vectors; tissue clearing; CRISPR genome editing and construction of CRISPR vectors for targeting genes in neurons and glia; gene delivery to neural cells in vivo by viral infection and plasmid electroporation techniques) (1 CFU).
•Neural mechanisms underlying diseases and disorders of the nervous system, including neurodegenerative diseases as well as autism spectrum disorder, epilepsy, schizophrenia, and anxiety (2 CFU) -> Journal clubs
•EXPERT SECTION: National and international speakers will be invited to discuss specific, advanced topics (e.g., computational neuroscience and connectome analysis) (0.5 CFU).
Prof. Marco Mainardi (Lecture 2 CFU + Lab 0.25 CFU), Marco Dal Maschio (Lab 0.25 CFU), Elisa Greggio (Lab 0.25 CFU)
10 CFU: 9 CFU lecture-based lessons and 1 CFU laboratory
Specific sections will be:
•Anatomical and functional organization of the human nervous system (0.5 CFU).
•Cellular organization of the nervous system – neurons and glia biology, the blood-brain barrier (1 CFU).
•The properties of nerve cells, including the generation and conduction of propagated signaling (0.5 CFU).
•Evolution of the nervous system (0.5 CFU).
•Electrophysiological and molecular mechanisms of synaptic transmission, including neuronal excitability, neurotransmitters, and transmitter release (0.5 CFU).
•Functional, structural, and molecular aspects of synaptic plasticity. Short- and long-term plasticity; structure and plasticity of dendritic spines; key molecular mediators of synaptic plasticity; experimental techniques for studying the synapse proteome.
Learning and memory. Main types of memory; behavioral methods for the study of memory; relationship between synaptic plasticity and memory.
Memory engrams: definition, experimental techniques for engram study, limitations of current approaches to the study of engrams (1.5 CFU).
•Sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system (0.5 CFU).
•Neural mechanisms of movement and basal ganglia regulation (0.5 CFU).
•Advanced approaches in neurobiology: electrophysiology techniques, optogenetic techniques, imaging techniques, quantitative neurobiology, molecular neuroscience (e.g., methods for preparing purified cell cultures of defined neuronal and glial cells; preparation and stereotaxic delivery of lentiviral vectors; tissue clearing; CRISPR genome editing and construction of CRISPR vectors for targeting genes in neurons and glia; gene delivery to neural cells in vivo by viral infection and plasmid electroporation techniques) (1 CFU).
•Neural mechanisms underlying diseases and disorders of the nervous system, including neurodegenerative diseases as well as autism spectrum disorder, epilepsy, schizophrenia, and anxiety (2 CFU) -> Journal clubs
•EXPERT SECTION: National and international speakers will be invited to discuss specific, advanced topics (e.g., computational neuroscience and connectome analysis) (0.5 CFU).
- Docente: Laura Civiero
- Docente: Marco Mainardi