Students will be introduced to the current understanding of modes of signaling compartmentalization, including mechanisms of organelles positioning, protein subcellular localization and locales of second messengers (Ca2+, cAMP, ROS microdomains) at membrane contact sites.
Some key questions on membrane contacts sites will be addressed: What is a membrane contact site? Which are the characteristics and composition of membrane contact sites? Which molecules reside at contact sites? Do they have a structural or functional role?
The course will provide an overview of the dynamics of contact sites involving different organelles both in physiological and pathological conditions, as well as of the methods used for their analysis.
Some key questions on membrane contacts sites will be addressed: What is a membrane contact site? Which are the characteristics and composition of membrane contact sites? Which molecules reside at contact sites? Do they have a structural or functional role?
The course will provide an overview of the dynamics of contact sites involving different organelles both in physiological and pathological conditions, as well as of the methods used for their analysis.
- Teacher: Marta Giacomello
- Teacher: Luigi Leanza