The course aims to provide the student with the main tools for planning effective modern and effective synthetic strategies.
Contents:
Chemo-, regio and diastereoselectivity in organic transformations.
Metal-halogen exchange, ortho-lithiation.
1,2-, 1,4- and 1,6-addition reactions.
Diastereoselectivity of the aldol and related reactions (Mannich, Michael, Mukaiyama). Principal stereodeterminging models. Stabilised enolates reactivity (Mukaiyama Silyl enol ethers, Boron-enolates, Tin-enolates). Other carbanion reactions (sulphonium and sulphoxonium ylides, Julia reaction, Darzens reaction, and related transformations).
Olefination reactions and related methods for the construction of double bonds.
Reductions and oxidation methods for functional group interconversion.
Modern synthetic approaches
Applications and relevance of high throughput experiments (THE) and design of experiments in the synthesis of organic molecules.
Recent synthetic approaches in data science.
The course will be delivered in English
Contents:
Chemo-, regio and diastereoselectivity in organic transformations.
Metal-halogen exchange, ortho-lithiation.
1,2-, 1,4- and 1,6-addition reactions.
Diastereoselectivity of the aldol and related reactions (Mannich, Michael, Mukaiyama). Principal stereodeterminging models. Stabilised enolates reactivity (Mukaiyama Silyl enol ethers, Boron-enolates, Tin-enolates). Other carbanion reactions (sulphonium and sulphoxonium ylides, Julia reaction, Darzens reaction, and related transformations).
Olefination reactions and related methods for the construction of double bonds.
Reductions and oxidation methods for functional group interconversion.
Modern synthetic approaches
Applications and relevance of high throughput experiments (THE) and design of experiments in the synthesis of organic molecules.
Recent synthetic approaches in data science.
The course will be delivered in English
- Docente: Luca Dell'Amico