The Comparative Physiology course focuses on the mechanisms underlying animal functions, from genes to organ systems, and on how environmental challenges have shaped unique adaptations. The main goal is to provide fundamental knowledge of the morphology and integrated functions of animal organisms, emphasizing structure–function relationships, the evolution of organs and systems, and adaptive responses to environmental conditions. A comparative approach will be adopted across representative groups of invertebrates and vertebrates. The course is complemented by invited guest lectures and a structured Journal Club, providing exposure to current research and fostering critical scientific discussion.